Study on the Pharmacokinetics of Qianlietai Tablets after Oral Adminstration in Rabbits
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Graphical Abstract
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Abstract
An analytical method for the determination of stachydrine concentration in rabbits after oral administration with 4% suspension of tablet powder was established. The pharmacokinetics in rabbits is a two compartment model. The main pharmacokinetic parameters are: Cmax is 6.29±0.84 μg/mL, Tmax is 3.36±0.64 h; T1/2α is 5.35±3.79 h; T1/2β is 32.38±24.33 h; AUC is 208.15±118.4 μg/(mL·h).
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