Application of UV Spectrophotometry-NMR Methodology in Research on Recognition Properties of Receptors Based on Deoxycholic Acid for Phenolic Compounds

Under the conventional heating condition, molecular tweezers a-d derived from deoxycholic acid were synthesized using deoxycholic acid methyl ester as the spacer, aryl hydrazine and carbamate as arms. Selective recognition properties of these molecular tweezers for phenol, p-methoxyphenol and m-methoxyphenol have been investigated by UV-Vis spectra titration and ¹H NMR study. The results indicate this type of molecular tweezers can form 1:1 supramolecular complex with phenol, p-methoxyphenol and m-methoxyphenol. The association constants (Ka) and Gibbs free energy changes (-△G⁰) for the supramolecular complexes have also been determined.